Overview
This study was conducted to evaluate the short-term stability of reconstituted GLP-1, a lyophilized research compound, when stored at refrigerated temperatures (2–8°C) for a duration of 8 weeks. The focus was to monitor any potential degradation in peptide purity or loss in weight over time that could affect its viability in in-vitro research applications.
Study Design
- Sample: Lyophilized GLP-1 reconstituted with ultra filtered lab water
- Storage Conditions: Refrigerated at 2–8°C
- Time Points: Baseline (Day 0), 4 Weeks, 6 Weeks, 8 Weeks
- Testing Method: HPLC LCMS
- Third-Party Lab: Janošik Analytics
COA References
| Time Point | COA Link |
|---|---|
| Baseline | View COA |
| 4 Weeks | View COA |
| 6 Weeks | View COA |
| 8 Weeks | View COA |
Results Summary
| Time Point | Avg. Weight (mg) | Avg. Purity (%) | Δ Weight vs. Baseline | Δ Purity vs. Baseline |
|---|---|---|---|---|
| Baseline | 13.97 | 99.594 | – | – |
| 4 Weeks | 13.997 | 99.812 | +0.19% | +0.22% |
| 6 Weeks | 14.013 | 99.660 | +0.31% | +0.07% |
| 8 Weeks | 13.980 | 99.296 | +0.07% | -0.30% |
Analysis
The data shows that reconstituted GLP-1 maintained strong physical and chemical stability over the 8-week observation period. Weight measurements varied less than 0.05 µL/mg from the baseline, indicating no notable loss due to evaporation or structural degradation. Purity peaked slightly at the 4-week mark and trended slightly downward by Week 8, though all values remained above 99.2%.
Conclusion
GLP-1 demonstrates excellent short-term stability under refrigeration. The results support continued in-vitro research use up to 8 weeks post-reconstitution without significant loss of weight or chemical integrity. These findings offer confidence for labs and institutions needing flexible research windows with reliable compound performance.
Disclaimer: For research use only. Not intended for human or veterinary use. Information presented is for educational purposes.